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Literature summary extracted from

  • Dementiev, A.; Silva, A.; Yee, C.; Li, Z.; Flavin, M.T.; Sham, H.; Partridge, J.R.
    Structures of human plasma beta-factor XIIa cocrystallized with potent inhibitors (2018), Blood Adv., 2, 549-558 .
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.4.21.38 in complex with benzamidine or 3-((1-aminoisoquinolin-6-yl)phenyl)boronic acid, vapor diffusion method, using 0.2 M ammonium iodide, 2.2 M ammonium sulfate Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.38 3-((1-aminoisoquinolin-6-yl)phenyl)boronic acid
-
 Homo sapiens
3.4.21.38 antithrombin minor inhibitory activity Homo sapiens
3.4.21.38 benzamidine
-
 Homo sapiens
3.4.21.38 plasminogen activator inhibitor 1 minor inhibitory activity Homo sapiens
3.4.21.38 serpin C1 esterase inhibitor
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.38 factor XI + H2O Homo sapiens
-
 factor XIa + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.38 Homo sapiens P00748
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.38 blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.38 factor XI + H2O
-
 Homo sapiens factor XIa + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.38 beta-factor XIIa
-
 Homo sapiens
3.4.21.38 beta-FXIIa
-
 Homo sapiens
3.4.21.38 FXIIa
-
 Homo sapiens
3.4.21.38 Hageman factor
-
 Homo sapiens